Sigil of Resilience

High alchemy turns Sigil of Resilience into 6,000 gp. Buying one at 50,000 gp (its guide price, as it has not traded today) and casting with a nature rune at 138 gp costs 50,138 gp. That is a loss of 44,138 gp per cast at its guide price, so it is not worth alching for profit right now.