Sigil of the Alchemist

High alchemy turns Sigil of the Alchemist into 6,000 gp. Buying one at 50,000 gp (its guide price, as it has not traded today) and casting with a nature rune at 138 gp costs 50,138 gp. That is a loss of 44,138 gp per cast at its guide price, so it is not worth alching for profit right now.